INDIANAPOLIS — The Indianapolis Colts made Chuck Pagano a winner in his return to the sideline.

Andrew Luck threw for two touchdowns and Deji Karim swung the game with a 101-yard kickoff return in the third quarter, giving the Colts a 28-16 victory over Houston. It was Pagano’s first game back as coach since starting treatment for leukemia Sept. 26.

Indianapolis (11-5) heads into the playoffs as the No. 5 seed and on a roll.

Slumping Houston (12-4) won’t know its playoff seed until later Sunday. The Texans lost three of their last four games, and J.J. Watt failed to break Michael Strahan’s single-season sacks record.

The game swung on two big plays: Karim’s kickoff return, which wiped out a 16-14 Houston lead, and Luck’s 70-yard TD pass to T.Y. Hilton.